buy stromectol for humansStromectol 3 mg tablets Dr Lee Hong Boon, PhD
Group Leader for Drug Discovery
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Dr Lee obtained a First Class Degree in Organic Chemistry at the University of Cambridge in 1996, where she was supported by the Lee Foundation. In the next three years, she pursued her PhD research with Prof Shankar Subramanian at the Department of Chemistry, University of Cambridge where she researched on new strategies of preparing small molecules rapidly for drug discovery processe supported by a studentship from AstraZeneca Pharmaceutical (formerly known as Zeneca Pharmaceutical). Following her PhD, she won a research fellowship from the Wellcome Trust, UK to continue her research in making small molecule mimics of biologically-active proteins under the guidance of Prof Kevin Burgess at Texas A&M University, USA. Dr Lee joined CARIF in January 2002 and she currently leads a team of chemists and biologists to research on ways to tap into the Malaysian biodiversity for natural compounds to fight cancer.
Objectives of Drug Discovery Team:
- To select and prepare crude extracts from plants, bacteria and marine organisms
- To test the natural extracts using the assays in our pipeline
- To isolate and elucidate structure of bioactive compounds
- To study the anti-cancer pathways of the bioactive compounds
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Selected Awards for Drug Discovery Team
- American Chemical Society-Institut Kimia Malaysia Travel Award to present at 244th xenical farmacia onlinexenical orlistat online ACS National Meeting for Dr Lee Hong Boon, Aug 2012
- 7th European Zebrafish Meeting at Edinburgh, Scotland Travel Award for Dr. Lee Hong Boon, July 2011
- IFCB International Training Program in Cell & Molecular Biology 2010 at Academia Sinica, Taipei, Taiwan Travel Award for Ms Lam May Lynn, November 2010
- British High Commission Award to host the 1st UK-Malaysia Conference on Drug Discovery for Cancer Using Natural Products Kuala Lumpur Malaysia, Jan 2010
- 13th Asian Chemical Congress Shanghai China – British High Commission Travel Award for Dr Lee Hong Boon, Sep 2009
- International Phytochemical Society of Europe Travel Award Italy for Ms Tang Yee Voon, Sep 2008
- 5th International Conference on Porphyrins & Phthalocyanines Moscow Russia Travel Award for Mr Fadzly Adzhar, Jul 2008
- British Association for Cancer Research/European Association for Cancer Research Symposium Nottingham UK Travel Award for Mr Lim Siang Hui, Jun 2008
- Wellcome Trust Advanced Course Bursary Cambridge UK for Dr Lee Hong Boon, Jun 2008
- European Science Foundation-Coorperation in Science & Technical Research (ESF-COST) High Level Research Conference Italy Travel Award for Ms Nurkhalida Kamal, Apr 2008
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Given that up to 74% of all cancer therapies were originally developed from natural products and that Malaysia is one of the tenth most biodiverse countries in the world with a wealth of natural products, we have combined our expertise in chemistry and biology of cancer to develop methodology for the identification of anti-cancer compounds from natural products.
1. We have drawn together the expertise and resources from more than 10 Malaysian and international organizations to identify the most promising anti-cancer compounds. To date, we have screened over 4500 natural extracts, identified 3 compounds which we are testing in animal cancer models and filed one patent for a novel class of compounds. We plan to partner with industry to further develop these compounds into cancer drugs.
2. In addition we helped established the first investigator-led clinical trial using a European-approved drug Foscan in a new cancer treatment modality in Malaysia known as photodynamic therapy (PDT). This study has been concluded due to slow recruitment but of the 5 patients treated under the trial setting, 4 were randomized to the PDT arm. Of the 4 patients, 1 passed away due to another recurrence while the other 3 are still disease free after 24 months of follow up. The results do indicate that PDT could be an effective treatment for NPC patients who are not cured from the initial round of chemo and radiation.