Around 5,000 Malaysian women are diagnosed with breast cancer every year, most of them aged between 30 and 60 years, where nearly half of those affected are under 50-years of age. At Cancer Research Malaysia, we are conducting research to find better ways to accurately identify women who are at high risk of developing breast cancer, conducting research to better understand how to cure the disease, and conducting research to help us improve patient support through patient navigation.
We are reversing the prevalence of breast cancer. We are reversing the toll breast cancer takes in our families and our communities.
THE MYBRCA AND MYMAMMO PROGRAMME generic zoloft cost without insurance100mg of zoloft for anxiety
Since the 1850s, we have known that some cancers occur in families, and breast cancer is a cancer with a strong familial component. By studying the genes that go wrong in our own cells which make us more likely to develop breast cancer, we now have realistic opportunities to transform predictive medicine and cancer screening. Instead of screening all women over the age of 50, we now know that some women are at higher risk and may require screening as early as 25 years old, others may require screening starting at a later age, and some others may have such low lifetime risk that there is limited benefit to screening. By studying the genes and lifestyle factors which make each woman different, we aim to build better ways of accurately predicting risk so that we can target prevention and screening to help reduce the burden of breast cancer in future generations of Malaysian women.
To find out the genes and lifestyle factors which cause breast cancer, we are studying women who have developed breast cancer and compare these with healthy women from the same population. Until end of Dec 2014, more than 2,900 Malaysian breast cancer patients from University Malaya (UM) and Sime Darby Medical Centre have participated in the “Malaysian Breast Cancer Genetic Study” dubbed MyBrCa (my-bra-kah) and 1,900 healthy Malaysian women have participated in the “More than a Mammo” programme. MyBrCa and “More than a Mammo” determine how genes and lifestyle contribute to breast cancer and using these data, we aim to build a risk assessment tool so that Malaysian women can accurately determine their risk of breast cancer.
Together with the International Breast Cancer Association Consortium, we have increased our knowledge of the number of breast cancer genes from 10 to more than 100. This research now opens up the possibility that we can more accurately identify women at risk of breast cancer.
Using genetic testing methods, we have analysed the role of breast cancer genes, such as BRCA1 and BRCA2 in Malaysian breast cancer patients. These patients are then offered specialist services to take appropriate screening and prophylactic steps to reduce their risk to cancer under our Familial Research Programme.
These patients also help us determine what is the risk of developing cancer for a woman who inherits a gene in BRCA1 or BRCA2. This is particularly urgent because although the risk to Caucasian BRCA carriers (such as Angelina Jolie) are known, the risk to Asian women are not yet known and could be lower because of differences in lifestyle factors such as the number of children we have, how long we breast feed for and other lifestyle factors.
In addition, we have analysed the role of other genes which may cause an increased risk to breast cancer and contributed to international studies such as the Breast Cancer Association Consortium to identify new breast cancer genes. Collectively, we have now identified 50% of the excess familial risk to breast cancer and our current project is to use next generation sequencing methods to identify the remaining excess familial risk.
Contribute to our research by participating in the “MyBrCa” or “More than a Mammo” research studies. To find out more, please email firstname.lastname@example.org.
“The MyBrCa Research Programme’s Genetic Testing and Genetic Counselling has helped me understand my risk and how I can manage my risk. My parents and siblings have also been tested. Though I am worried about the risk to my children, I now know what to expect and how to guide her in the future”,
Ms. PL Leong, breast cancer survivor. buy cheap generic arimidexAnastrozole generic cost
Mammograms are the most effective way of detecting cancer. We now know that women who have mammographic dense breasts (mammograms with many white areas) have up to 5 times higher risk of developing breast cancer compared to women than do not have mammographic dense breasts, and that genes and lifestyle factors can affect mammographic density. We also know that Asian women have mammographic denser breasts, but ironically, lower risk to breast cancer compared to Caucasian women, but we do not understand why.
Buoyed by the success of the “More than a Mammo” programme, the “Be a Boob Buddy” Campaign aims to remind every woman to be a Boob Buddy to her loved ones, to encourage men to also be Boob Buddies and to remind each woman to set a date for her mammogram/breast self-examination..
Supported by funds raised through the Sime Darby LPGA and in collaboration with Ramsay Sime Darby Healthcare, the “More than a Mammo” programme seeks to understand the genes and lifestyle factors that contribute to mammographic density and breast cancer risk. Any Malaysian woman aged over 40 can participate in the programme and all research participants receive a mammogram at a subsidised fee of RM50 (normal fee RM235).
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We are studying the lifestyle and genetic determinants of mammographic density and aim to combine these to develop a personalized risk score for each woman.
Contribute to our efforts to develop more accurate ways of calculating risk by participating in the “More than Mammo” Programme.
To participate, you need to:
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- be a Malaysian woman.
- be 40 years of age or older*.
- have no personal history of breast cancer.
- have not gone for a mammogram for the last 12 months.
- donate a small amount of blood.
- complete a questionnaire about factors that relate to breast cancer such as whether you have even been pregnant, your age when menstrual periods began, your exercise and other habits.
- have a mammogram at Breast Care Centre, Sime Darby Medical Centre Subang Jaya.
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*If you are less than 40 years of age and have a close relative with breast cancer, you should consult your doctor about the benefits and limitations of mammograms. With a doctor’s referral, you are still eligible for the study.
To make an appointment, please call: +603 5639 1340
Breast Care Centre,
1st Floor Outpatient Centre,
Sime Darby Medical Centre Subang Jaya,
1, SS12/1A, 47500 Subang Jaya, Selangor.
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Being told you have cancer is terrible news. Most women go blank, feel that their world has come crashing down and are enveloped by feelings of fear, helplessness, sometimes despair. One of the biggest challenges is knowing what to do next.
“Patient Navigation” refers to a system or a professional who helps patient understand the decisions that they need to make and helps them “navigate” the services that they need. Patient navigation programmes are designed to improve cancer care and patient outcomes through one-on-one educational and assistance – from initial screening to diagnosis to treatment.
Supported by funds raised through the Sime Darby LPGA and in collaboration with University Malaya, Cancer Research Malaysia has developed a Patient Decision Aid and a Patient Navigation video in different languages and dialects used in Malaysia. The decision aid and video are tools used by patient navigators to guide newly diagnosed patients through the maze of decisions and treatment options and empowers the patients to make their own treatment decision.
Supported by funds raised through the Sime Darby LPGA and in collaboration with Hospital Tengku Ampuan Rahimah Hospital in Klang, Cancer Research Malaysia has established a Pink Ribbon patient Navigation centre at HTAR Klang and are working closely with doctors, patients and the community to improve patient survival.
Patient navigators are trained to assist and ‘anchor’ the patient so that they do not get lost in the complicated cancer treatment system, much like a navigator boat that brings a ship adrift in the vast ocean safely back to shore. Our aims are to reduce late presentation of breast cancer through increasing awareness in the community, to improve patient journey by supporting them through the financial, logistical, knowledge and other barriers, and to improve survivorship by supporting patients after the completion of treatment.
Cancer Research Malaysia’s ultimate aim is to educate, empower, and encourage women – in short, to navigate patients towards the right channels in their vulnerable state of mind upon breast cancer diagnosis. For details or to get a copy of the Decision Aid and Video, please contact Ms Maheswari Jaganathan at email@example.com or call: +603 5639 1874.
“We need to empower breast cancer patients, most of whom are women who only have basic health knowledge doxycycline price walmartbuy doxycycline malaria tablets and who need help to understand the complex journey of a cancer patient – from surgical options, to options for chemotherapy and radiotherapy, where to get treatment and so on”,
Prof. Dr. Yip Cheng Har, an internationally reowned consultant breast surgeon.